New York Yankees at Chicago White Sox odds, picks and predictions

The New York Yankees (70-49) and Chicago White Sox (28-91) clash in the opener of a 3-game series at Guaranteed Rate Field. The opening pitch is scheduled for 8:10 p.m. ET. Let's analyze BetMGM Sportsbook's lines around the Yankees vs. White Soxodds and make our expert MLB picks and predictions for the best bets.

Season series: Yankees lead 3-0

New York took 2 of 3 games from the Texas Rangers over the weekend, and a Yankee club that struggled across much of June-July is 10-4 since July 27.

The hapless White Sox are 1-24 since July 10. For the season, Chicago's American League entry ranks 30th in MLB in scoring (3.08 runs per game) and 29th in run prevention (5.19 RPG).

Yankees at White Sox projected starters

RHP Luis Gil vs. LHP Ky Bush

Gil (12-5, 3.06 ERA) is tabbed for his 23rd start. He has a 1.11 WHIP, 4.4 BB/9 and 10.6 K/9 through 117 2/3 IP.

• Last outing: Win, 5 IP, 0 ER, 2 H, 5 BB, 6 K in 5-2 home victory vs. Los Angeles Angels Wednesday
• Career vs. White Sox: 1-0, 4.50 ERA (10 IP, 5 ER), 10 H, 3 BB, 19 K in 2 starts
• Threw season-high 107 pitches in his last start

Bush (0-1, 6.75 ERA) is making his 2nd MLB start. He allowed 3 earned runs on 2 hits and 5 walks with 3 K's in 4 innings in his debut, a 5-1 loss at the Oakland A's Aug. 5.

• Owns 2.89 ERA, 1.12 WHIP with 42 BB and 94 K in 99 2/3 IP in minors this season (Double- and Triple-A)
• Is ranked as No. 8 pitching prospect in organization

Who's going yard? Here's a breakdown of today's best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Yankees at White Sox odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:50 a.m. ET.

• Moneyline: Yankees -350 (bet $350 to win $100) | White Sox +260 (bet $100 to win $260)
• Run line (RL)/Against the spread (ATS): Yankees -2.5 (-130) | White Sox +2.5 (+110)
• Over/Under (O/U): 9 (O: -115 | U: -105)

Yankees at White Sox picks and predictions

Prediction

White Sox 6, Yankees 5

Moneyline

The WHITE SOX (+260) took 2 of 3 from New York in the Yanks' last visit to Chicago's South Side (Aug. 7-9, 2023). New York is just 13-17 against left-handed starters.

This line has steamed toward the visiting nine in the morning, and the plus price on the Pale Hose is just ripe enough to pick. But consider this one a sliver of a lean, and with a Bush being a 2nd-time starter, this one sets up as a conservative partial-unit play.

Gil threw 107 pitches in his last start. His only other 100-plus outing came on June 14, and the start after that saw him yield 7 runs in 1 1/3 innings.

TAKE CHICAGO (+260).

Run line/Against the spread

PASS: Against a mediocre Yankee bullpen, the White Sox are worth the shot at big plus money on the ML.

Over/Under

The Over has cashed in 13 of New York's last 16 games and in 7 straight on the road.

Gil has benefited from a favorable .232 batting average on balls in play. Bush is in for a different level opponent after pitching mostly in Double-A and then facing the A's in his MLB debut.

FanDuel Sportsbook has better leverage here. BACK THE OVER 9 (-112).

Play our free daily Pick’em Challenge and win! Play now!

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW. Follow SportsbookWire on Twitter/X andlike us on Facebook.

Fantasy baseball help from BaseballHQ.com:

Subscribe now to dominate the competition.

More MLB Picks and Predictions!

Colorado Rockies at Arizona Diamondbacks odds, picks and predictions

Kansas City Royals at Minnesota Twins odds, picks and predictions

Texas Rangers at Boston Red Sox odds, picks and predictions